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Search Results for " Angiotensin II "

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176

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天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T35834L	(Sar¹)-Angiotensin II acetate		RAAS
	(Sar¹)-Angiotensin II acetate, an analogue of Angiotensin II, is a specific agonist of angiotensin AT1 receptor. It binds to brain membrane-rich particles, with a Kd of 2.7 nM. It can stimulate protein synthesis and cell...		RAAS
TP1528	Angiotensin I/II (1-5)	Angiotensin I/II 1-5	RAAS , Others
	Angiotensin I/II (1-5) is a peptide (ASP-ARG-VAL-TYR-ILE) that contains the amino acids 1-5 and is converted from Angiotensin I/II.		RAAS , Others
TP1579	Angiotensin I/II (1-6)	Angiotensin I/II 1-6	RAAS , Others
	Angiotensin I/II (1-6) is a peptide (ASP-ARG-VAL-TYR-ILE-HIS) that contains the amino acids 1-6 and is converted from Angiotensin I/II peptide.		RAAS , Others
T7575L	[Sar1, Ile8]-Angiotensin II 3TFA	[Sar1, Ile8]-Angiotensin II 3TFA(37827-06-8(free base))	Others
	[Sar1, Ile8]-Angiotensin II 3TFA ([Sar1, Ile8]-Angiotensin II 3TFA (37827-06-8(free base))) is a peptide that has multiple effects on vascular smooth muscle.		Others
T7575L1	[Sar1, Ile8]-Angiotensin II acetate		RAAS
	[Sar1, Ile8]-Angiotensin II acetate activates both the NADPH and NADH oxidases, and stimulates superoxide anion formation in vascular smooth muscle cells. [Sar1, Ile8]-Angiotensin II acetate has multiple effects on vascu...		RAAS
TP1017L	Angiotensin II 5-valine TFA	Angiotensin II 5-valine TFA(58-49-1 free base)	RAAS
	Angiotensin II 5-valine TFA is an agonist of angiotensin receptor.		RAAS
T8560	Angiotensin II human acetate	Ang II acetate,DRVYIHPF acetate,Angiotensin II acetate	Apoptosis , RAAS
	Angiotensin II human acetate (DRVYIHPF acetate) is a vasoconstrictor that mainly acts on the AT1 receptor.		Apoptosis , RAAS
T35834	(Sar1)-Angiotensin II	(Sar¹)-Angiotensin II
	The substitution with Sar at position 1 of angiotensin II resulted in a partial agonistic activity.
T7575	[Sar1, Ile8]-Angiotensin II	[Sar1, Ile8]-Angiotensin II(3TFA)	RAAS , Others
	[Sar1, Ile8]-Angiotensin II(3TFA) is a peptide that has multiple effects on vascular smooth muscle.		RAAS , Others
T38697	[Tyr(P)4] Angiotensin II
	[Tyr(P)4] Angiotensin II is a peptide that exerts a multitude of effects on vascular smooth muscle. These effects include the contraction of normal arteries, as well as the induction of hypertrophy or hyperplasia in cult...
T36622	Angiotensin I/II (1-6) (TFA)
	Angiotensin I/II (1-6) TFA is a chemical compound comprising amino acids 1-6. It is derived from the Angiotensin I/II peptide, which is formed by the cleavage of the precursor angiotensinogen by renin. The resulting Angi...
TP1017	Angiotensin II 5-valine	Valine angiotensin II,5-L-Valine angiotensin II
	ngiotensin II 5-valine is an angiotensin II analog which is an agonist at angiotensin receptors.
TP1609	Angiotensin II (1-4), human
	Angiotensin II is a potent direct vasoconstrictor, causing arteries and veins to constrict, so leading to an increase in blood pressure. Angiotensin also potentiates the release of norepinephrine by a direct action on po...
T5824	Angiotensin II (3-8), human	Angiotensin IV	RAAS
	Angiotensin II (3-8), human is a less effective agonist at the angiotensin AT1 receptor.		RAAS
TP1522	Angiotensin II (5-8), human
	Angiotensin II (5-8) is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II
TP2464	Pentasarcosyl angiotensin II	(Sar)5 aii
	Pentasarcosyl angiotensin II is a synthetic analog of angiotensin II.
TP1224	[Sar1, Ile8]-Angiotensin II TFA	Angiotensin 2 TFA,AngiotensinII TFA
	[Sar1, Ile8]-Angiotensin II (TFA) is a peptide compound that exerts various effects on vascular smooth muscle. These effects include the contraction of normal arteries as well as the hypertrophy or hyperplasia of culture...
T10323	Angiotensin II (3-8), human TFA		RAAS
	Angiotensin II (3-8), human (TFA) is an angiotensin AT1 receptor agonist with less activity.		RAAS
TP1661	Angiotensin II (1-4), human TFA
	Angiotensin II is a potent direct vasoconstrictor, causing arteries and veins to constrict, so leading to an increase in blood pressure.
TP1929L1	Saralasin acetate(34273-10-4 free base)		RAAS
	Saralasin acetate is a Non-selective angiotensin II antagonist.		RAAS
T2531	Eprosartan Mesylate	SKF-108566J	RAAS
	Eprosartan Mesylate (SKF-108566J) is a competitive and reversible Angiotensin II Receptor Blocker.		RAAS
T74142	Angiotensin II human TFA
	Angiotensin II human TFA, a potent vasoconstrictor within the renin/angiotensin system, plays a pivotal role in human blood pressure regulation primarily through interactions with the G-protein-coupled receptors Angioten...
TP2370	Angiotensin pentapeptide	Angiotensin II (4-8),(Des-1,2,3)angiotensin II
	Angiotensin pentapeptide is a peptide.
T6340	Enalaprilat Dihydrate	MK-422,MK-422 Dihydrate	RAAS , Autophagy
	Enalaprilat Dihydrate (MK-422 Dihydrate) （IC50=1.94 nM） is a potent angiotensin-converting enzyme (ACE) inhibitor.		RAAS , Autophagy
T76634	(Sar1,Ile4,8)-Angiotensin II
	(Sar1,Ile4,8)-Angiotensin II is a functionally selective agonist for the angiotensin II type 1 receptor (AT1R), enhancing insulin-stimulated signaling of the insulin receptor (IR) and glycogen synthesis. It boosts the in...
T1461	Candesartan	CV 11974	RAAS
	Candesartan (CV 11974) is an angiotensin II receptor blocker used widely in the therapy of hypertension and heart failure.		RAAS
T3461	Losartan Carboxylic Acid	EXP-3174,E-3174	RAAS
	Losartan Carboxylic Acid (E-3174) a potent AT1 antagonist (Kis: 0.57 nM, rat; 0.67 nM, human), producing a depressor response and vasodilatation. Losartan Carboxylic Acid , a metabolite of losartan, is more potent than l...		RAAS
T6595	Moexipril hydrochloride	Moexipril HCl,RS-10085,SPM 925,CI-925	Apoptosis , RAAS
	Moexipril hydrochloride (Moexipril HCl) is a potent orally active nonsulfhydrylangiotensin converting enzyme (ACE)inhibitor, used for the treatment of hypertension and congestive heart failure.		Apoptosis , RAAS
T1615	Irbesartan	SR-47436,BMS-186295	Apoptosis , RAAS
	Irbesartan (SR-47436) is an Angiotensin 2 Receptor Blocker. The mechanism of action of irbesartan is as an Angiotensin 2 Receptor Antagonist.		Apoptosis , RAAS
T28540	Ripisartan	UP 269-6,UP-2696,UP 2696,UP-269-6,UP269-6	RAAS
	Ripisartan (UP-269-6) is a potent and specific angiotensin II receptor antagonist that inhibits angiotensin II-mediated sympathetic tachycardia responses.		RAAS
T1484L	Perindopril erbumine	S9490-3,Perindopril tert-butylamine salt	Apoptosis , RAAS , MRP
	Perindopril erbumine (S9490-3) is the tert-butylamine salt of perindopril, the ethyl ester of a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Upon hydrolysis, Perindopril er...		Apoptosis , RAAS , MRP
T2400	Candesartan Cilexetil	TCV-116	Apoptosis , RAAS
	Candesartan Cilexetil (TCV-116) is an angiotensin II receptor antagonist (IC50: 0.26 nM). After hydrolysis of candesartan cilexetil to candesartan during gastrointestinal absorption, candesartan selectively competes with...		Apoptosis , RAAS
T13390	ZD 7155 hydrochloride		RAAS
	ZD 7155 hydrochloride is an angiotensin II receptor type 1 (AT1 receptor) antagonist.		RAAS
T0215	Losartan potassium	DuP-753 potassium,MK 954,DuP 753	RAAS
	Losartan potassium (DuP-753 potassium) , an Angiotensin II Receptor Blocker, selectively and competitively blocks the binding of angiotensin II to the angiotensin I (AT1) receptor.		RAAS
T3178	BIBS 39		RAAS
	BIBS 39 is a new nonpeptide angiotensin II (AII) receptor antagonist.		RAAS
T0215L	Losartan	DuP-753	RAAS
	Losartan (DuP-753) is an angiotensin II receptor antagonist.		RAAS
T67848	Valsartan Methyl Ester		RAAS
	Valsartan Methyl Ester is a potent angiotensin II receptor antagonist, IC50= 0.06uM.		RAAS
T7663L	Angiotensin 1/2 (1-9) TFA(34273-12-6(free base))		Others
	Angiotensin 1/2 (1-9)TFA is containing the amino acids 1-9 that are converted from Angiotensin I/II peptide.		Others
T40220L	TRV055 acetate	TRV055 acetate (25849-90-5 Free base)	RAAS
	TRV055 acetate is a ligand of angiotensin II type 1 receptor and stimulates cellular Gq-mediated signaling.		RAAS
T27762	L-162,313	L-162313,L 162,313,L162,313	RAAS
	L-162,313 is an ANG II receptor agonist, a nonpeptide that mimics the biological actions of angiotensin II and induces an increase in MAP.		RAAS
T14942	CGP48369		RAAS
	CGP48369 is a potent angiotensin II receptor antagonist with antihypertensive effects that enhances endothelium-dependent relaxation of coronary arteries in spontaneously hypertensive rats.		RAAS
T7577	Angiotensin III, human, mouse	Angiotensin III, human, mouse(3TFA)	RAAS
	Angiotensin III, human, mouse (Angiotensin III, human, mouse(3TFA))(3TFA) is an endogenous angiotensin II receptor (AT2R) agonist(IC50s of 0.648 nM).		RAAS
T3281	Delapril hydrochloride	indalapril,Alindapril Hydrochloride,Delapril Hydrochloride,CV 3317	RAAS
	Delapril hydrochloride (indalapril) is a prodrug; it is converted into two active metabolites, 5-hydroxy delapril diacid and delapril diacid. These metabolites bind completely to and inhibit angiotensin-converting enzyme...		RAAS
T6067	PD 123319	(S)-(+)-PD 123319,PD123319	RAAS
	PD 123319 ((S)-(+)-PD 123319) is a potent, selective AT2 angiotensin II receptor antagonist.		RAAS
T1518	Olmesartan Medoxomil	CS 866,Benicar	RAAS
	Olmesartan Medoxomil (Benicar) is an angiotensin II type 1 receptor blocker that is used to manage hypertension.		RAAS
T7797	Tasosartan	WAY-ANA 756	RAAS
	Tasosartan (WAY-ANA 756) is an antagonist of angiotensin II type 2 (AT2) receptor (IC50 = 1.2 nM).		RAAS
T14337	Buloxibutid	AT2 receptor agonist C21	RAAS
	Buloxibutid (AT2 receptor agonist C21) is a novel and selective small molecule angiotensin II AT2 receptor agonist with Ki values of 0.4 nM and 10 μM for AT2 and AT1 receptors, respectively.		RAAS
T2531L	Eprosartan	KF-108566J free base,Teveten	RAAS
	Eprosartan (SKF-108566J free base) is a selective and competitive nonpeptide angiotensin II receptor antagonist with high affinity for AT1 receptor subtypes and can be used as an antihypertensive agent.Eprosartan has an ...		RAAS
T65740	Trityl candesartan
	Trityl candesartan is a crucial intermediate used in the synthesis of Candesartan and Candesartan cilexetil, which are angiotensin II receptor antagonists.
T5111	4-Bromomethyl-2-cyanobiphenyl		Others
	4'-Bromomethyl-2-cyanobiphenyl is a halogenated benzonitrile used in protein-binding studies of quinoxaline angiotensin II receptor antagonists.		Others

Compounds

(Sar¹)-Angiotensin II acetate

T35834L

Synonym:

Target: RAAS

Angiotensin I/II (1-5)

TP1528

Synonym: Angiotensin I/II 1-5

Target: RAAS, Others

Angiotensin I/II (1-6)

TP1579

Synonym: Angiotensin I/II 1-6

Target: RAAS, Others

[Sar1, Ile8]-Angiotensin II 3TFA

T7575L

Synonym: [Sar1, Ile8]-Angiotensin II 3TFA(37827-06-8(free base))

Target: Others

[Sar1, Ile8]-Angiotensin II acetate

T7575L1

Synonym:

Target: RAAS

Angiotensin II 5-valine TFA

TP1017L

Synonym: Angiotensin II 5-valine TFA(58-49-1 free base)

Target: RAAS

Angiotensin II human acetate

T8560

Synonym: Ang II acetate,DRVYIHPF acetate,Angiotensin II acetate

Target: Apoptosis, RAAS

(Sar1)-Angiotensin II

T35834

Synonym: (Sar¹)-Angiotensin II

Target:

[Sar1, Ile8]-Angiotensin II

T7575

Synonym: [Sar1, Ile8]-Angiotensin II(3TFA)

Target: RAAS, Others

[Tyr(P)4] Angiotensin II

T38697

Synonym:

Target:

Angiotensin I/II (1-6) (TFA)

T36622

Synonym:

Target:

Angiotensin II 5-valine

TP1017

Synonym: Valine angiotensin II,5-L-Valine angiotensin II

Target:

Angiotensin II (1-4), human

TP1609

Synonym:

Target:

Angiotensin II (3-8), human

T5824

Synonym: Angiotensin IV

Target: RAAS

Angiotensin II (5-8), human

TP1522

Synonym:

Target:

Pentasarcosyl angiotensin II

TP2464

Synonym: (Sar)5 aii

Target:

[Sar1, Ile8]-Angiotensin II TFA

TP1224

Synonym: Angiotensin 2 TFA,AngiotensinII TFA

Target:

Angiotensin II (3-8), human TFA

T10323

Synonym:

Target: RAAS

Angiotensin II (1-4), human TFA

TP1661

Synonym:

Target:

Saralasin acetate(34273-10-4 free base)

Angiotensin II human TFA

T74142

Synonym:

Target:

Angiotensin pentapeptide

TP2370

Synonym: Angiotensin II (4-8),(Des-1,2,3)angiotensin II

Target:

Enalaprilat Dihydrate

T6340

Synonym: MK-422,MK-422 Dihydrate

Target: RAAS, Autophagy

(Sar1,Ile4,8)-Angiotensin II

Losartan Carboxylic Acid

T3461

Synonym: EXP-3174,E-3174

Target: RAAS

Moexipril hydrochloride

T6595

Synonym: Moexipril HCl,RS-10085,SPM 925,CI-925

Target: Apoptosis, RAAS

Irbesartan

T1615

Synonym: SR-47436,BMS-186295

Target: Apoptosis, RAAS

Ripisartan

T28540

Synonym: UP 269-6,UP-2696,UP 2696,UP-269-6,UP269-6

Target: RAAS

Perindopril erbumine

T1484L

Synonym: S9490-3,Perindopril tert-butylamine salt

Target: Apoptosis, RAAS, MRP

Candesartan Cilexetil

T2400

Synonym: TCV-116

Target: Apoptosis, RAAS

ZD 7155 hydrochloride

Synonym: DuP-753 potassium,MK 954,DuP 753

Valsartan Methyl Ester

T67848

Synonym:

Target: RAAS

Angiotensin 1/2 (1-9) TFA(34273-12-6(free base))

Synonym: TRV055 acetate (25849-90-5 Free base)

Target: RAAS

L-162,313

T27762

Synonym: L-162313,L 162,313,L162,313

Angiotensin III, human, mouse

T7577

Synonym: Angiotensin III, human, mouse(3TFA)

Target: RAAS

Delapril hydrochloride

T3281

Synonym: indalapril,Alindapril Hydrochloride,Delapril Hydrochloride,CV 3317

Target: RAAS

PD 123319

T6067

Synonym: (S)-(+)-PD 123319,PD123319

Target: RAAS

Olmesartan Medoxomil

T1518

Synonym: CS 866,Benicar

Synonym: AT2 receptor agonist C21

Target: RAAS

Eprosartan

T2531L

Synonym: KF-108566J free base,Teveten

4-Bromomethyl-2-cyanobiphenyl

T5111

Synonym:

Target: Others

カタログ番号	製品名	別名	ターゲット
T7040	Angiotensin II human	DRVYIHPF,Angiotensin II,Hypertensin II,Ang II	Apoptosis , RAAS
	Angiotensin II human (Ang II) is a biologically active peptide, a vasoconstrictor. Angiotensin II interacts with AT1R and AT2R to regulate blood pressure, stimulate sympathetic nerves, and increase aldosterone biosynthes...		Apoptosis , RAAS
TN7109	Prosaikogenin G		RAAS
	Prosaikogenin G is a compound isolated from the roots of Buleurum bicaule Helm (Apiaceae) and id a derivative of Saikosaponin d in the gastrointestinal tract, exhibiting a significant inhibitory effect on angiotensin II...		RAAS
T8270	Deserpidine	Harmonyl	RAAS
	Deserpidine (Harmonyl) is only found in individuals that have used or taken this drug. It is an ester alkaloid drug isolated from Rauwolfia canescens (family Apocynaceae) with antipsychotic and antihypertensive propertie...		RAAS
T2836	Isorhamnetin	3-methylquercetin,3'-Methylquercetin,Isorhamnetol,3'-Methoxyquercetin	MEK , PI3K , Endogenous Metabolite
	Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin. Quercetin is an important dietary flavonoid with in vitro antioxidant activity. Isorhamnetin prevents endothelial cell injuries from oxidized LD...		MEK , PI3K , Endogenous Metabolite
T37298	Spinacine		Endogenous Metabolite
	Spinacine has been isolated from spinach and the roots of Panax ginseng. This conformationally constrained amino acid is a structural element in certain biologically active compounds as glucagon antagonists and angiotens...		Endogenous Metabolite
T38593	1-Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone
	Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone9, a quinolone alkaloid derived from Evodia rutaecarpa, is a potent antagonist of the angiotensin II receptor, displaying an IC50 value of 48.2 μM.
T81229	Safflor yellow B
	Safflor Yellow B mitigates angiotensin II-induced injury in human umbilical vein cells by modulating Bcl-2/p22(phox) expression and demonstrates neuroprotective effects [1].
T75697	1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone
	1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone, a diacylglycerol acyltransferase inhibitor and angiotensin II receptor blocker, exhibits IC50 values of 20.1 μM and 34.1 μM, respectively. Additionally, it demonstr...

天然物製品

Angiotensin II human

T7040

Synonym: DRVYIHPF,Angiotensin II,Hypertensin II,Ang II

Target: Apoptosis, RAAS

Synonym: 3-methylquercetin,3'-Methylquercetin,Isorhamnetol,3'-Methoxyquercetin

Target: MEK, PI3K, Endogenous Metabolite

Spinacine

T37298

Synonym:

Target: Endogenous Metabolite

1-Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone

1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone

T75697

Synonym:

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPH-02268	AGTR2 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.
TMPH-02267	AGTRAP Protein, Human, Recombinant (His & Myc & SUMO)	Human	E. coli
	Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decr...
TMPK-00383	ACE2/ACEH Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	ACE2 (Angiotensin I Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ACE2 include Severe Acute Respiratory Syndrome and Neurogenic Hypertension.The protein encoded by this gene belongs to the angio...
TMPJ-00386	ACE2/ACEH Protein, Human, Recombinant (HEK293, His & Avi), Biotinylated	Human	HEK293 Cells
	Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypept...
TMPK-00382	ACE2/ACEH Protein, Human, Recombinant (hFc & Avi), Biotinylated	Human	HEK293 Cells
	ACE2 (Angiotensin I Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ACE2 include Severe Acute Respiratory Syndrome and Neurogenic Hypertension.The protein encoded by this gene belongs to the angio...
TMPK-00551	ACE2/ACEH Protein, Cynomolgus, Recombinant (His & Avi)	Cynomolgus	HEK293 Cells
	ACE2 (Angiotensin I Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ACE2 include Severe Acute Respiratory Syndrome and Neurogenic Hypertension.The protein encoded by this gene belongs to the angio...
TMPK-00552	ACE2/ACEH Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated	Cynomolgus	HEK293 Cells
	ACE2 (Angiotensin I Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ACE2 include Severe Acute Respiratory Syndrome and Neurogenic Hypertension.The protein encoded by this gene belongs to the angio...
TMPY-02574	Chymase 1 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	The STR polymorphism in the CMA1 gene is associated with asthma and that this association is even stronger with atopic asthma. CMA1 and IL-4 in atopic asthma and for IL-4 in atopy in general. The local angiotensin II sys...
TMPH-01041	Carboxypeptidase A6 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	May be involved in the proteolytic inactivation of enkephalins and neurotensin in some brain areas. May convert inactive angiotensin I into the biologically active angiotensin II. Releases a C-terminal amino acid, with p...
TMPJ-00964	PRCP Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Lysosomal Pro-X Carboxypeptidase (PRCP) belongs to the peptidase S28 family. PRCP is detected in many tissues, with highest levels observed in placenta, lung, and liver. It is also present in the heart, brain, pancreas, ...
TMPY-01027	Mast Cell Protease-1/MCPT-1 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Mast Cell Protease 1 (MMCP-1), also known as MCP-1, MCPT-1 and β-chymase, is a member of the Chymase family of chymotrypsin-like serine proteases. MCPT-1 is a 26 kDa β-chymase that is a component of mast cell granules. I...
TMPH-02274	JAK2 Protein, Human, Recombinant (His)	Human	E. coli
	Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cyto...